The Blues have won the trophy seven times including last year’s success which was completed with a Wembley final victory over Manchester United.
We beat Luton Town in December 2-1, but our FA Cup clash at 20:00 (UK) will be the first at Kenilworth Road since 1961.
At this stage last season, we beat Bristol City 3-0 away with two goals from Phil Foden and another from Kevin De Bruyne.
We go into the game having conceded just once in our last nine FA Cup games with none this season from our victories against Huddersfield and Tottenham.
Check out the best stats ahead of the game above...
LUTON V CITY COVERAGE
Our official app allows you to follow all of the action from the Kenilworth Road in one place.
Minute-by-minute text updates will begin in our Matchday Centre two hours before kick-off, while our Matchday Live show will begin just before 19:00 (UK).
Paul Dickov and Nicky Weaver will join Natalie Pike in the studio on the latest Matchday Live show, offering their expert insight before, during and after the action.
They will also answer viewer questions throughout the broadcast, with audience participation actively encouraged on Matchday Live. To get in touch, send a WhatsApp to: +447537186538.
During the game you can also listen to live audio commentary from Alistair Mann and Michael Brown while our text commentary continues.
Make sure to have push notifications turned on as well, so you can be alerted to key moments in the action, including goals, red cards and the team news.
You’ll be able to watch brief and extended highlights – and a CITY+ full-match replay - from 12:00 (UK) on Wednesday.
