We travel to the Bruchwegstadion in Germany for a 17:00 (UK) kick-off on Tuesday 27 February.
You can see every single moment live on mancity.com and our official app with a CITY+ subscription.
Brian Barry-Murphy‘s side qualified for the last-16 by topping Group G with 14 points from our six matches.
Mainz reached this stage after eliminating Barcelona on penalties following a 2-2 draw. The German side originally qualified for that match through the domestic champions path.
Should this match be a draw after 90 minutes, the winner will be decided on penalties.
If we progress, we will host either AZ Alkmaar or Porto in the quarter-finals.
Our best finish in the competition came in 2017/18 when we reached the semi-finals before losing to eventual winners Barcelona.
CITY+ subscribers will see the stream live shortly before the match begins.
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